Endocrine Abstracts

Introduction: Prader–Willi syndrome [PWS] is a complex genetic disorder with hypothalamic pituitary dysfunction that includes obesity, diabetes and behaviour changes. Obesity in PWS is due to decrease of oxytocin neurons and leptin resistance causing hyperphagia. Prader–Willi syndrome is associated with high incidence of altered glucose metabolism. The etiology for diabetes in PWS may be related to morbid obesity and resultant insulin resistance.<p class="abstext...

Background: Infants born to mothers who are deficient in vitamin D are at risk of developing vitamin D deficiency and hypocalcaemia.We present a case report on infantile hypocalcemic seizures secondary to vitamin D deficiency followed by persistent hypomagnesemia.Case description: A 4-week-old term male baby born by uncomplicated pregnancy was brought due to acute onset seizures which terminated with IV lorazepam. He was...

Background: Although it accounts for small number (1–2%) of diabetes cases, MODY is especially important to be picked up by health care providers because of the implications of the correct diagnosis on clinical management and family counselling. MODY should be suspected when a patient <25 years old presents with symptoms of diabetes, who has a family history of diabetes/ MODY, with negative diabetes autoantibodies screen, and/or suboptimal response to...

Background: Diabetic ketoacidosis (DKA) in children and young adults carries significant morbidity and mortality relating to complications such as cerebral oedema. Acute kidney injury (AKI) is a rare but potentially fatal complication of DKA. We present three cases of DKA complicated by AKI.Case 1: A 9-year-old girl presented with severe DKA at diagnosis. She was treated with intravenous fluids and insulin as per protocol. She had oliguria and haematuria...

Introduction: Use of degludec [tresiba] in children and adolescents with type 1 diabetes was approved by EC 2015 and FDA in December 2016. Degludec is a new ultra-long acting basal insulin with terminal half-life of approximately 25 hours and duration of action of more than 42 hours. Constant release of insulin throughout the day leads to better control of blood glucose for more than 24 hours with significant reduction in HbA1c.Aim: To compare and assess...